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目的:运用虚燥更平方作用于治疗雌性大鼠高血压病(更年期),观察大鼠性激素指标治疗前后的变化,探讨虚燥更平方对性激素的影响。方法:将雌性大鼠高血压病(更年期)模型,随机分成空白组、模型组、中药组,观察3组雌激素(E2)、促卵泡刺激素(FSH)、睾酮(T)、促黄体生成素(LH)、孕酮(PRO)、催乳素(PRL)水平,并做统计分析比较。结果:虚燥更平方可使雌性大鼠高血压病(更年期)中药组治疗后血清E2水平升高,T、FSH水平降低,三者有统计学意义(P<0.05),PRO、PRL、LH无统计学意义(P>0.05)。结论:(1)虚燥更平方对改善雌性大鼠高血压病(更年期)患者性激素水平具有一定的调节作用。(2)通过比较中药组和模型组治疗前后性激素相关指标水平的变化,说明雌性大鼠高血压病(更年期)紊乱的性激素与高血压病的发生、发展关系密切。
OBJECTIVE: To observe the changes of sex hormones before and after treatment in rats by treating the hypertensive disease (menopause) in female rats with the treatment of deficiency and dryness more squarely, and to explore the effect of deficiency of dryness and flatness on sex hormones. Methods: Hypertension (menopause) model in female rats was randomly divided into blank group, model group and traditional Chinese medicine group. The levels of estrogen (E2), follicle stimulating hormone (FSH), testosterone (T) (LH), progesterone (PRO), prolactin (PRL) levels, and make statistical analysis and comparison. Results: The results showed that the serum levels of E2 and T, FSH in the TCM group were significantly higher than those in the control group (P <0.05), PRO, PRL and LH No statistical significance (P> 0.05). Conclusions: (1) Dryness and Freshenousness can regulate the level of sex hormones in hypertensive patients (menopause) of female rats. (2) By comparing the changes of sex hormone-related indicators before and after treatment in traditional Chinese medicine group and model group, it shows that sex hormones with hypertension (menopausal) disorders in female rats are closely related to the occurrence and development of hypertension.