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目的 了解 HBV感染的各种标记物的自然消长情况。方法 对某地职业人群 HBV感染进行随访研究。结果 1995年 HBs Ag阳性率 14.83% (35 4/ 2 387) ,1996年为 14.84% ,1997年为12 .0 3% ;抗 - HBs阳性率 1.2 2 % (2 9/ 2 387) ,年平均消长率 2 7.2 7% ,HBe Ag年阴转率 78.2 7% ,HBe Ag阳转率 15 .0 4% ,感染呈持续性与波动性 ;HBV感染的动态变化过程存在一定的群组效应 ,抗 - HBs和抗 - HBc的变化以阳转为主 ,抗 - HBs和抗 - HBc在各个年龄组均可出现。 HBV感染的模式共 10种 ,以“小三阳”型为主占 46 .0 5 % ,其次为“单阳”型 ,占 30 .79% ,再次为“大三阳”型 ,占5 .0 9% ,其余模式的比率较小。结论 人群 HBV感染标记物以阳转为主 ,阴转很少。抗 - HBc较抗- HBs稳定 ,感染 HBV时 ,抗 - HBc阳性率也较高。提示感染者可携带 HBV标记物渡过相当长的时期 ,甚至一生
Objective To understand the natural growth and decline of various markers of HBV infection. Methods A follow-up study of HBV infection in a local occupational population was conducted. Results The positive rate of HBs Ag was 14.83% (35 4/2 387) in 1995, 14.84% in 1996 and 12 .0 3% in 1997. The positive rate of anti - HBs was 1.2 2% (29/38 387) The growth rate of HBe Ag was 78.2 7% and the positive rate of HBeAg was 15.04%. The infection was persistent and fluctuating. The dynamic change of HBV infection had some group effect, The changes of HBs and anti - HBc are mainly in the positive phase, anti - HBs and anti - HBc appear in all age groups. The total number of HBV infection was 10, accounting for 46.0%, followed by “single yang” type, accounting for 30.79%, again “big yangyang” type, accounting for 5.0 9%, the ratio of the remaining models smaller. Conclusion The HBV infection markers in the population are mainly yang-yang, with little yin-yang. Anti-HBc is more stable than anti-HBs. When infected with HBV, the positive rate of anti-HBc is also higher. Suggesting that infected persons can carry HBV markers over a long period of time, or even life