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关于中耳炎积液(OME)的发生机理,长期以来认为是由咽鼓管器质性狭窄或阻塞所引起。但是,自从文献报告表明咽鼓管阻塞或狭窄的病人实际上仅有低的OME发生率以来,对OME的临床病因学来说,传统理论就有值得商榷的地方。本文目的是要澄清在动物模型上顽固性OME发生所必须的条件。作者用20只成年猫(27耳)分三组进行实验。1组9只14耳,在用10～15mg/kg盐酸氯胺酮和10～15mg/kg戊巴比妥钠腹膜内注射全麻后,横断腭帆张肌和切除翼突钩去破坏咽鼓管的通气机能,为了减少炎性反应,术日腹膜内注射氢化可的松10mg/kg,然后每周进行鼓室压测量和鼓室
The pathogenesis of otitis media effusion (OME) has long been thought to be caused by structural stenosis or occlusion of the eustachian tube. However, since the literature reports that patients with obstruction or stenosis of the eustachian tube have virtually only a low incidence of OME, the traditional theory is questionable for the clinical etiology of OME. The purpose of this paper is to clarify the conditions necessary for the development of intractable OME in animal models. The authors used 20 adult cats (27 ears) to perform experiments in three groups. Group 1, group 9, with 14 ears. After general anesthesia was induced with 10-15 mg / kg ketamine hydrochloride and 10-15 mg / kg sodium pentobarbital intraperitoneally, transected palatal lobe and excision of the wing prongs to destroy the eustachian tube Ventilator function, in order to reduce the inflammatory response, intraperitoneal injection of hydrocortisone intraoperative day 10mg / kg, and then tympanometry and tympanometry