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人类单克隆IgM抗脂A抗体(HA—IA)治疗严重革兰氏阴性菌败血症是有效的,但以往尚无婴儿应用的报道。病例男,8个月。因发热、呕吐和嗜睡而入院。入院时休克、发绀,腹部皮肤出现紫癜,无颈强或局灶性神经系统体征。实验室检查除白细胞减少外,其它项目正常。脑脊液清晰。血涂片可见到革兰氏阴性双球菌,经鉴定为B组脑膜炎球菌,给予静脉输液及抗生素,开始有所改善,但入院16小时后病情突然恶化,意识障碍,格拉斯哥(Glasgow)昏迷6级,低血压及末梢循环差. 给予气管插管及辅助呼吸。在心搏停止复苏后,给予多巴胺及异丙基肾上腺素维持动脉血压。转
Human monoclonal IgM anti-lipid A antibody (HA-IA) is effective in the treatment of severe Gram-negative septicemia, but no previous reports of infant use have been reported. Case male, 8 months. Due to fever, vomiting and lethargy and hospitalization. Shock, cyanosis, purpura on the skin of the abdomen, no strong neck or focal neurological signs on admission. Laboratory tests except leukopenia, the other items are normal. Cerebrospinal fluid clear. Gram-negative diphtheria was seen on blood smear, which was identified as meningococcal group B and given intravenous fluids and antibiotics, beginning to improve, but suddenly deteriorating 16 hours after admission, unconsciousness, Glasgow coma 6 Grade, low blood pressure and poor peripheral circulation. Give tracheal intubation and assisted breathing. After cardiac arrest stopped, dopamine and isoproterenol were given to maintain arterial blood pressure. turn