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用促黄体激素生成激素(LHRH)类似物治疗晚期和转移的前列腺癌,经临床应用已证实其效果,并未发现明显的毒性作用。本文报告两例前列腺癌用D-Trp~6—LHRH 类似物治疗,突然发生严重的异常情况。例1 70岁的男性前列腺癌患者,1981年曾用乙烯雌酚治疗,每日3mg,治疗三个月.1984年元月患者因胸部和腰部轻微疼痛入院。经X 线检查发现有骨、肺转移。超声检查主动脉旁淋巴结亦有转移.该病人接受D-Trp~6-LHRH 类似物的治疗(每日皮下注射一次500ug,计划共治疗7天,第8天改用长效类似物制剂,皮下注射100ug).但治疗第4天,患者突然出现剧烈疼痛,需要麻醉止痛剂,体征有肝
The use of luteinizing hormone-producing hormone (LHRH) analogues for the treatment of advanced and metastatic prostate cancer has been confirmed by clinical use and no significant toxic effects have been found. In this paper, two cases of prostate cancer treated with D-Trp~6-LHRH analogues were reported to have sudden and severe abnormalities. Example 1 A 70-year-old man with prostate cancer who had been treated with ethylene-estradiol for 3 months daily for three months in 1981. In January 1984, he was hospitalized with minor chest and lumbar pain. X-ray examination revealed bone and lung metastases. Ultrasound examination of paraaortic lymph nodes also metastases. The patient was treated with D-Trp~6-LHRH analogue (daily subcutaneous injection of 500ug, planned for a total of 7 days, and on the 8th day a long-acting analogue preparation was used subcutaneously Injected 100ug). But on the 4th day of treatment, the patient suddenly experienced severe pain and required anesthetic analgesics, signs of liver