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目的:探讨氯胺酮联合其他药物应用于小儿麻醉的临床效果。方法:选取腹股沟疝疝囊高位结扎患儿100例,随机分为氯胺酮一异丙酚(KP)和氯胺酮一咪唑安定(KM)两组,分别给予氯胺酮联合异丙酚以及氯胺酮联合咪唑安定麻醉。结果:KM组与KP组HR(心率)与MAP(平均动脉压)在麻醉诱导后以及手术开始后5min、15min相比以及与自身术前相比均有明显差异(P<0.05);不良反应方面KM组恶心呕吐的发生率明显高于KP组(P<0.05);其余指标两组之间无明显差异(P>0.05)。结论:氯胺酮联合异丙酚以及咪唑安定进行小儿麻醉都是有效的,但是氯胺酮联合异丙酚在小儿术中麻醉的效果显著优于氯胺酮联合咪唑安定,为小儿手术麻醉较为合理的联合用药,推荐儿科临床广泛使用。
Objective: To investigate the clinical effect of ketamine combined with other drugs in pediatric anesthesia. Methods: One hundred children with high ligation of inguinal hernia sac were selected and randomly divided into ketamine-propofol (KP) and ketamine-midazolam (KM) groups. Ketamine, propofol and ketamine combined with midazolam were given respectively. Results: There was a significant difference (P <0.05) between HR (heart rate) and MAP (mean arterial pressure) in the KM group and the KP group after induction of anesthesia and at 5 and 15 minutes after the start of surgery and before surgery (P <0.05) The incidence of nausea and vomiting in KM group was significantly higher than that in KP group (P <0.05). There was no significant difference between the other two groups (P> 0.05). Conclusions: Ketamine combined with propofol and midazolam are effective in pediatric anesthesia. However, ketamine combined with propofol has a significantly better effect on anesthesia in children than ketamine combined with midazolam, which is a reasonable combination therapy for pediatric anesthesia. Pediatric clinical widely used.