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Straub氏(1907)①于海兔(Aplysia)离体心脏实驗中观察到一种現象,即毒菌硷(Muscarin)对心脏的抑制作用——負性心肌作用——于数小时后,内行消失,而对于再度加入的毒菌硷呈现了耐受現象;但是将套管內的溶液,于作用业已消退的时候,吸出而代之以未含特殊藥物的实驗溶液,反而又呈現了抑制作用,如果将吸出的溶液加于另一海兔离体心脏,則仍呈現抑制作用,此种現象于电魚(Torpedo)离体心脏实驗中亦可观察到,但在青蛙离体心脏实驗中則观察不到这种现象。
Straub’s (1907) ① a phenomenon observed in isolated heart experiments of Aplysia, in which the inhibitory effect of Muscarin on the heart-negative myocardial effect-disappeared in a few hours, While the addition of toxoid showed resistance; however, when the solution in the cannula was withdrawn and the experimental solution containing no special drugs was sucked out, the solution in the cannula showed an inhibitory effect. If The aspirated solution was added to the isolated heart of another sea urchin, but the inhibition was still observed. This phenomenon was also observed in the torpedo heart experiment, but not in the frog heart experiment To this phenomenon.