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目的:研究紫杉醇(PTX)对比多西他赛(TXT)联合顺铂(DDP)、氟尿嘧啶(5-FU)一线治疗晚期转移性胃癌的近期疗效和不良反应。方法:将48例晚期转移性胃癌患者分为治疗组和对照组。治疗组(n=23)采用PCF(PTX 160 mg/m2,静脉滴入,d1;DDP 60 mg/m2,静脉滴入,d1;5-FU2.5 g/m2,用便携微量泵静脉持续滴入48 h)方案;对照组(n=25)采用DCF(TXT 70 mg/m2,静脉滴入,d1;DDP60 mg/m2,静脉滴入,d1;5-FU2.5 g/m2,用便携微量泵静脉持续滴入48 h)方案化疗。至少完成2个周期化疗后评价两组有效率(RR)、疾病控制率(DCR)及不良反应。结果:两组均可评价疗效。治疗组RR为52.2%,DCR为82.6%;对照组RR为48.0%,DCR为80.0%。两组比较差异均无统计学意义,P值均>0.05。治疗组与对照组主要不良反应有粒细胞减少、脱发、恶心呕吐和过敏反应等。两组不良反应比较,3~4级粒细胞减少差异有统计学意义,P<0.05。结论:PCF方案治疗晚期转移性胃癌疗效与DCF方案相似,不良反应PCF方案优于DCF方案,值得进一步研究。
Objective: To investigate the short-term efficacy and side effects of paclitaxel (PTX) versus docetaxel (TXT) plus cisplatin (DDP) and 5-fluorouracil in the treatment of advanced metastatic gastric cancer. Methods: 48 patients with advanced metastatic gastric cancer were divided into treatment group and control group. The patients in the treatment group (n = 23) were treated with PCF (PTX 160 mg / m2 iv, d1; DDP 60 mg / m2 iv, d1; 5-FU 2.5 g / 48 h). The control group (n = 25) received DCF (TXT 70 mg / m2, iv, d1; DDP 60 mg / m2, iv, d1; Trace pump intravenous infusion of 48 h) regimen chemotherapy. After completing at least 2 cycles of chemotherapy, the two groups were evaluated for RR, DCR and adverse reactions. Results: Both groups could evaluate the curative effect. The treatment group RR was 52.2%, DCR was 82.6%; control group RR was 48.0%, DCR was 80.0%. There was no significant difference between the two groups, P> 0.05. The treatment group and the control group the main adverse reactions are neutropenia, hair loss, nausea and vomiting and allergic reactions. Two groups of adverse reactions, grade 3 to 4 neutropenia difference was statistically significant, P <0.05. Conclusions: The efficacy of PCF regimen in treatment of advanced metastatic gastric cancer is similar to that of DCF regimen. PCF regimen is superior to DCF regimen and deserves further study.