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目的 观察尼莫地平对椎基底动脉供血不足 (VBI)患者的疗效。 方法 对 60例BVI患者分别用尼莫地平 (治疗组 )和脉络宁 (对照组 )静滴治疗 ,疗程 14d ,对比观察其临床疗效及经颅多普勒超声 (TCD)、血液流变学改变。 结果 治疗组起效时间快 ,2 4h内有效率为 66 7% ,72h内达 93 3% ,总有效率达 93 3% ;对照组分别为6 7%、16 7%、40 %。治疗组TCD及血液流变学指标改善明显 ,2组比较差异有显著性 (P <0 0 1) ,未见明显毒副作用。 结论 尼莫地平治疗VBI安全有效。
Objective To observe the efficacy of nimodipine in patients with vertebrobasilar insufficiency (VBI). Methods Sixty patients with BVI were treated with nimodipine (treatment group) and Mailuoning (control group) intravenously. The course of treatment was 14 days. The clinical efficacy, transcranial Doppler echocardiography (TCD), hemorheological changes . Results The effective time of treatment group was 66.7% in 24 hours, 93.3% in 72 hours and 93.3% in control group. The control group was 67%, 167% and 40% respectively. The TCD and hemorheology indexes of the treatment group improved obviously, the difference between the two groups was significant (P <0.01), and no obvious side effects were found. Conclusion Nimodipine is safe and effective in treating VBI.