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目的 了解静脉吸毒队列保持人群社会人口学和高危行为特征以及HIV血清阳转率。方法 于 2 0 0 2 - 11,在四川省凉山地区从社区招募了HIV抗体阴性的静脉吸毒人群前瞻性研究队列 333人。分析队列本底的静脉吸毒人群社会人口学和HIV高危行为特征与队列保持率的关系 ,以及在队列第 1次 6个月随访时进行HIV抗体检测来估算HIV血清阳转率。结果 静脉吸毒人群队列半年的HIV血清阳转率为 4 0 4× 10 - 2 /人年 (95 %CI:0 5 0～ 7 5 9)和保持率为 74 8% (2 4 9/333)。在单因素χ2 分析中 ,民族和文化程度分别与队列保持率的差异有统计学意义。在多因素Logistic回归分析中 ,民族与队列保持率的差异有统计学意义 ,其OR值为 0 4 8(95 %CI:0 2 9～ 0 80 )。结论 本研究队列静脉吸毒人群HIV血清阳转率高 ;彝族或其他少数民族静脉吸毒人群队列保持率低。
Objectives To understand the socio-demographic and high-risk behavior of HIV-cohorts and their HIV seroconversion rates. METHODS: A prospective cohort of 333 HIV-negative intravenous drug users was recruited from the community in Liangshan Prefecture, Sichuan Province from February 2-11. To analyze the relationship between socio-demographic and HIV high-risk behavioral characteristics and cohort maintenance in intravenous drug users and to estimate HIV seroconversion rates at the first 6-month follow-up of HIV cohorts. Results The HIV seroconversion rate in the cohort of intravenous drug users was 4 0 4 × 10 -2 / year (95% CI: 0 5 0 ~ 7 5 9) and retention rate was 74 8% (2 49/333) . In the univariate χ2 analysis, there was statistically significant difference between nationality and education level and the cohort maintenance rate respectively. In the multivariate Logistic regression analysis, there was a significant difference between the nationality and the cohort retention rate, with an OR of 0 48 (95% CI: 0 2 9 0 80). Conclusions HIV seropositivity among cohort of intravenous drug users in this study is high, and cohort retention rates of Yi drug addicts or other minority drug users are low.