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含氟的有机化合物是近代有机化学中一个較为新穎的領域。除了因为氟的有机化合物具有特殊的物理和化学性質以外,它的生理活性也饒有兴趣。最早受人注意的是氟乙酸类化合物,这类化合物具有强烈的生理毒性,而被用作杀虫(鼠)药。在多种药物中,氟代衍生物也颇引入注意。二次大战期間,合成了各种喹啉、叮啶类的氟化物作为抗瘧药。虽然由于它們的毒性没有应用,但是他們的生理作用是肯定的。此外,在含氟的局部麻醉,磺胺,碸类等类型中,也分别显示出它們的生理作用。氨基酸的氟化物具有多种效用,氟代苯丙氨酸对某些細菌、芽胞的抑制作用大于磺胺噻唑,氟代苯絲氨酸也具有相当的抗菌作用。最近,在可的松类化合物中也出現了氟代可的松。由于氟的生理活潑性,引起了許多肿瘤药物工作
Fluorine-containing organic compounds are a relatively novel field in modern organic chemistry. In addition to the special physical and chemical properties of fluorine-containing organic compounds, its biological activity is also of great interest. The earliest attention was paid to fluoroacetate compounds, which have a strong physiological toxicity and have been used as insecticides. In many drugs, fluoro derivatives have also attracted attention. During World War II, various quinoline and acridine fluorides were synthesized as antimalarials. Although they are not used because of their toxicity, their physiological role is certain. In addition, in the fluorine-containing local anesthesia, sulfonamides, steroids and other types, they also showed their physiological effects. Amino acid fluoride has a variety of effects, fluorophenylalanine inhibition of certain bacteria, spores greater than sulfathiazole, fluorobenzene serine also has a considerable antibacterial effect. Recently, fluorocortisone has also appeared in cortisone compounds. Due to the physiological activity of fluorine, many oncological drugs work