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Objective To investigate the changes of calcium regulating hormones in serum and bone mass in patients with diabetes mellitus.Methods The levels of estradiol (E2), testosterone (T), total triiodthyronine (TT3), total thyroid hormone(TT4), parathyroid hormone (PTH-SP), calci-tonin (CT) were measured in serum of 227 patients with diabetes and 268 healthy controls by radioim-munoassay, and bone mass density (BMD) at lumbar vertebrae, hip, foream were measured by dual energy X-ray absorptiometry (DEXA). The subjects were divided into three age groups.Results T of male in three age subgroups of diabetes was significantly lower (P<0.01 or P<0.05) and PTH was significantly higher (P< 0.001 or P< 0.01) than that in controls. BMD at lumbar 3, lumbar 4 in diabetes was lower than that in controls but BMD at hip, foream was higher.Conclusion The level of T declines and PTH increases in diabetes. Bone mass loss mostly occurs at lumbar vertebrae in diabetes patients.
Objective To investigate the changes of calcium regulating hormones in serum and bone mass in patients with diabetes mellitus. Methods The levels of estradiol (E2), testosterone (T), total triiodthyronine (TT3), total thyroid hormone (TT4), parathyroid hormone PTH-SP), calci-tonin (CT) were measured in serum of 227 patients with diabetes and 268 healthy controls by radioim- munoassay, and bone mass density (BMD) at lumbar vertebrae, hip, foream were measured by dual energy X- ray absorptiometry (DEXA). The subjects were divided into three age groups. Results T of male in three age subgroups of diabetes was significantly lower (P <0.01 or P <0.05) and PTH was significantly higher (P <0.001 or P <0.01 BMD at lumbar 3, lumbar 4 in diabetes was lower than that in controls but BMD at hip, foream was higher. Conlusion The level of T declines and PTH increases in diabetes. Bone mass loss mostly occurs at lumbar vertebrae in diabetes patients.