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与其他胺和酰胺衍生物的合成方法相比,过渡金属催化醇与各类胺和酰胺的脱水N-烷基化反应是一种相对绿色、原子经济性较高的方法,一般被称为“借氢”或“氢自动转移”反应及其方法学.近年来,在空气氛围下过渡金属催化醇与胺和酰胺的有氧脱水N-烷基化反应,可使用更稳定的金属催化剂、可在无配体、空气等更温和简单的条件下进行,也引起了人们的极大关注.主要介绍近年来过渡金属催化下醇与胺和酰胺在空气或者氧化剂作用下构建C—N,C=N键合成胺和酰胺衍生物以及亚胺类化合物的有氧脱水反应进展情况,同时也对相关有氧脱水C-烷基化反应进行简单介绍.相关反应的机理研究也将作适当讨论.
Compared with the synthesis of other amine and amide derivatives, the transition metal catalyzed dehydration of various alcohols and amides and N-alkylation of amides is a relatively green and atomic-economical method, commonly referred to as In recent years, the transition metal catalyzed the aerobic dehydration of alkylamines with amines and amides in the N-alkylation reaction in the air, the use of more stable Metal catalysts, which can be carried out under milder and simpler conditions without ligands and air, have also attracted great attention from people.It mainly introduces that transition metal-catalyzed conversion of alcohols with amines and amides in air or oxidant to C- N, C = N bond to amine and amide derivatives as well as the progress of the aerobic dehydration reaction of imine compounds as well as a brief introduction of the related aerobic dehydration C-alkylation reactions. Discuss properly.