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市售的口服棕榈酸氯霉素酯混悬剂(无味氯霉素)中含有香味剂如香草醛等,或是与其他药物如链霉素,四环素等组成复合制剂。本文报导四种这些制剂中,棕榈酸氯霉素酯的含量测定方法。 1.改进的美国药典(16版)方法:取4毫升口服棕榈酸氯霉素酯混悬剂(相当于125毫克氯霉素及含有20毫克香草醛香味剂)于4号垂熔玻璃漏斗中,加蒸镏水10毫升,迅速抽滤,再用蒸镏水10毫升抽洗两次,将垂熔漏斗移置于一干燥的250毫升的抽滤瓶上,用氯仿溶解残留物将溶液抽吸于
Commercially available oral chloramphenicol palmitate suspensions (odorless chloramphenicol) contain flavoring agents such as vanillin and the like, or with other drugs such as streptomycin, tetracycline and the like. This article reports four methods for the determination of chloramphenicol palmitate in these four formulations. 1. Improved USP (16th Edition) Procedure: Take 4 ml of oral chloramphenicol palmitate suspension (equivalent to 125 mg of chloramphenicol and 20 mg of vanillin flavor) in a No. 4 frit glass funnel , Add distilled water 10 ml, quickly filtered, and then distilled water 10 ml twice, the vertical funnel was placed in a dry 250 ml filter flask, the residue was dissolved in chloroform solution pumping Suck from