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胃复安是临床常用药物之一,用以治疗消化机能异常引起的恶心、呕吐等症状。我科于1990年1月～12月,对恶性滋养细胞肿瘤疾病的病人,采用长春新碱,顺铂方案治疗,常规用胃复安肌注或静脉注射,以减轻抗癌药物所致的消化道不良反应。在此期间,因胃复安致使4例患者发生6次锥体外系反应的症状,均经安定静脉注射后,获得缓解,并无后遗症。本文总结4例治疗体会,供参考。 临床资料 4例患者,年龄在23～35岁,均为恶性滋养细胞肿瘤的化疗病人。恶葡Ⅲ期2例,绒癌Ⅳ期2例,化疗方案为长春新碱,顺铂,大剂量一次性注射,胃肠道反应较重,表现为恶心,频繁呕吐,食欲减退等。为
Metoclopramide is one of the commonly used clinical drugs for the treatment of nausea, vomiting and other symptoms caused by abnormal digestive function. Our department in January 1990 to December, the patients with malignant trophoblastic tumor disease, the use of vincristine, cisplatin regimen, conventional metoclopramide intramuscular injection or intravenous injection to reduce anti-cancer drug-induced digestion Adverse reactions. During this period, 4 cases of patients with metoclopramide caused by extrapyramidal symptoms in 6 cases, were stable intravenous injection, were relieved, no sequelae. This article summarizes 4 cases of treatment for reference. Clinical data 4 patients, aged 23 to 35 years old, are malignant trophoblastic tumor chemotherapy patients. 2 cases of evil Portugal III, 2 cases of choriocarcinoma Ⅳ, chemotherapy regimens vincristine, cisplatin, high-dose one-time injection, gastrointestinal reactions heavier, manifested nausea, frequent vomiting, loss of appetite and so on. for