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药物、化学物质或生物毒素均可引起肾脏的结构或(和)功能损害,并可出现相应的临床过程。此类肾脏疾患一般统称为“中毒性肾病”.临床中毒性肾病大多数均系药物所引起,可表现为急性肾小管坏死、急性肾灌注不足、急慢性间质性肾炎及肾小球肾炎等。药物性中毒性肾病的发病机理较为复杂,并可因肾损害的类型不同而各有不同。大致说来,这一机理可涉及到肾小管上皮细胞中毒性损伤、免疫介导的各种损害、肾血流灌
Drugs, chemicals, or biological toxins can cause structural or (and) functional impairment of the kidneys, and the corresponding clinical course can occur. Such kidney disease generally referred to as “toxic nephropathy.” Most clinical toxic nephropathy are caused by drugs, can be manifested as acute tubular necrosis, acute renal insufficiency, acute and chronic interstitial nephritis and glomerulonephritis . The pathogenesis of drug-induced toxic nephropathy is more complicated and may vary depending on the type of renal impairment. Broadly speaking, this mechanism may be involved in the renal tubular epithelial cells, toxic injury, immune-mediated damage, renal perfusion