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作者于1985年6月至1987年5月两年内对美国加州北部12万名23～71月龄儿童进行了b型流感杆菌荚膜多糖(Hib-PRP)菌苗的接种。以回顾性监察方法考核,其免疫效果为68%(95%可信限为4～89%);以配比病例对照分析,其效果为69%(95%可信限为-13～91%)。采用多种手段确诊Hib病病例,除了临床的侵袭性症状外,还有实验室Hib培养阳性或胶乳凝集反应Hib抗原阳性的结果、临床监护和回顾性监察等记载。结果发现35例Hib病病例,患者年龄均在23～72月龄之间,其中34例Hib培养阳性。这些病例中27例在
The authors vaccinated 120,000 23- to 71-month-old children in northern California from February 1985 to May 1987 with influenza b capsular polysaccharide (Hib-PRP) vaccine. To retrospectively monitor the method of assessment, the immune effect was 68% (95% confidence limit of 4 to 89%); the proportion of case-control analysis, the effect was 69% (95% confidence limit of -13 to 91% ). The diagnosis of Hib disease by a variety of means, in addition to the clinical symptoms of invasive, but also laboratory Hib culture positive or latex agglutination Hib antigen positive results, clinical monitoring and retrospective monitoring records. The results showed that 35 cases of Hib disease, patients aged 23 to 72 months of age, of which 34 cases of Hib culture positive. 27 of these cases are present