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Objective: To develope two simple and accurate spectrophotometric methods for the determination of meloxicam (Ⅰ) in presence of its degradation products, 5 - methyl - 2 - aminothiazole (Ⅱ) and benzothiazine car boxylic acid (Ⅲ). Method: Both methods are based on the formation of chelate complexes of the studied drug with uranyl acetate and ferric chloride at room temperature in a methanolic medium. Results:The resulting complexes are stable for 24 hrs and show absorption maxima at 406 nm and 580 nm for uranyl and ferric complexes respectively. These methods are applicable over the concentration ranges of 10 - 100 and 37. 5 -300 μg·?mL-1 with mean recoveries of (99. 44±0. 48)% and(99. 42±0. 45)% ,and molar absorptivity of 4. 67×103 and 1. 029 × 103 respectively. Conclusion: Both methods are proved to be stability indicating as no interference was observed with the degradation products. The proposed methods were successfully applied to the determination of the drug in bulk powder , laboratory prepared mixtures containing different percentages of degradation products and pharmaceutical dosage forms.
Objective: To develope two simple and accurate spectrophotometric methods for the determination of meloxicam (Ⅰ) in presence of its degradation products, 5 - methyl - 2 - aminothiazole (Ⅱ) and benzothiazine car boxylic acid on the formation of chelate complexes of the studied drug with uranyl acetate and ferric chloride at room temperature in a methanolic medium. Results: The resulting complexes are stable for 24 hrs and show absorption maxima at 406 nm and 580 nm for uranyl and ferricues respectively (99.44 ± 0.48)% and (99.42 ± 0.45)%. The methods are applicable over the concentration ranges of 10 - 100 and 37.5 - 300 μg · mL-1 with the mean recoveries of , and molar absorptivity of 4. 67 × 103 and 1. 029 × 103 respectively. Conclusion: Both methods are proved to be stability indicating as no interference was observed with the degradation products. The proposed methods were successfully applied to the determination of the drug in bulk po wder, laboratory prepared mixtures containing different percentages of degradation products and pharmaceutical dosage forms.