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目的探讨肾嗜酸细胞腺瘤的临床病理学特点及诊断要点。方法对我院收治的肾嗜酸细胞腺瘤3例的临床资料、病理形态学及免疫组化结果进行分析,并结合文献对其诊断及鉴别诊断进行探讨。结果本组中肾占位2例,肾上腺占位1例。镜下可见肿瘤细胞排列呈实性巢索状、乳头状或呈腺泡结构,胞质丰富,嗜酸,间质少,伴透明样变性;瘤细胞呈圆形或多角形,细胞核圆形规则,染色质分布均匀,核仁位于中央,核分裂象少见。免疫组化显示CK、EMA表达均阳性,Vimentin、Hale胶体铁表达均阴性。病理诊断肾嗜酸细胞腺瘤。结论肾嗜酸细胞腺瘤较少见,提高对该病的认识,对避免误诊至关重要。
Objective To investigate the clinicopathological features and diagnosis of renal oncocytoma. Methods The clinical data, pathomorphology and immunohistochemistry results of 3 cases of renal oncocytoma admitted to our hospital were analyzed. The diagnosis and differential diagnosis of renal cell carcinoma were analyzed. Results The group accounted for 2 cases of kidney, adrenal space in 1 case. Microscopically, the tumor cells arranged in a solid nests, papillary or acinar structure, rich cytoplasm, eosinophilic, interstitial less with degeneration of transparent; tumor cells were round or polygonal, round nuclei rules , Chromatin distribution, nucleolus located in the center, mitotic rare. Immunohistochemistry showed that CK and EMA expression were positive, Vimentin, Hale colloid iron expression were negative. Pathological diagnosis of renal oncocytoma. Conclusions Renal acidophilic adenoma is rare, and increasing awareness of the disease is crucial to avoiding misdiagnosis.