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为了进一步评价１４Ｃ－尿素呼气试验（１４Ｃ－ｕｒｅａｂｒｅａｔｈｔｅｓｔ，１４Ｃ－ＵＢＴ）的临床诊断价值。５８例ＵＢＴ检测患者同时作快速尿素酶试验和细菌培养检测幽门螺杆菌（Ｈｐ），其中１３例在口服１４Ｃ－尿素胶囊后不同时间分别检测呼气中１４ＣＯ２活度。经受试者工作特征曲线（ＲＯＣ）分析，ＵＢＴ诊断临界值可在１５０～２００ｍｉｎ－１之间，其敏感性、特异性与快速尿素酶试验（ＲＵＴ）、细菌培养并行检测相当。患者呼气中１４ＣＯ２活度时间动态变化为Ｈｐ阳性５ｍｉｎ时即迅速上升，２０～５０ｍｉｎ时达到高峰，Ｈｐ阴性在所观察的２ｈ内未见有明显变化，这些结果提示ＵＢＴ是诊断Ｈｐ感染十分可靠和简便的一种方法。
In order to further evaluate the 14C-urea breath test (14C-ureabreathtest, 14C-UBT) clinical diagnostic value. Fifty-eight UBT patients underwent rapid urease test and bacterial culture to detect Helicobacter pylori (Hp), of which 13 patients were detected for 14CO2 activity in exhaled breaths at different times after oral administration of 14C-urea capsules. The receiver operating characteristic curve (ROC) analysis, UBT diagnostic threshold between 150 ~ 200min-1, its sensitivity and specificity and rapid urease test (RUT), bacterial culture parallel detection. The dynamic change of 14CO2 activity in patients’ expiration increased rapidly at 5 min of Hp positive and peaked at 20 ~ 50 min. No significant change of Hp negative occurred within 2 h observed. These results suggest that UBT is a reliable diagnosis of Hp infection And a simple way.