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氨茶碱用于临床已有70余年历史,近年来因提出了一些新看法,而引起麻醉工作者的注视,现综述如下。作用机理和生理效应氨茶碱由85％茶碱和15％乙二胺组成,主要起作用是茶碱,为临床上常用的平喘药。其作用机理围绕三个中心环节,也称三种假说: 一、使环磷酸腺苷(cAMP)破坏减少,cAMP是细胞功能活动的重要调节物质,cAMP的破坏与磷酸二酯酶有关。茶碱能抑制磷酸二酯酶,使cAMP破坏减少,细胞内cAMP水平提高。继而产生生理效应,使组胺和过敏反应慢反应物质(SRS-A)的释放减少,导致平滑肌松弛以及减轻支气管
Aminophylline has been used clinically for more than 70 years. In recent years, some new ideas have been proposed for anesthesia workers, and the following are summarized below. Mechanism of action and physiological effects Aminophylline consists of 85% of theophylline and 15% ethylenediamine, the main role is theophylline, clinically common asthma medicine. The mechanism of action around the three central areas, also known as three kinds of hypotheses: First, the reduction of cyclic AMP (cAMP), cAMP is an important regulator of cellular functional activity substances, cAMP destruction and phosphodiesterase related. Theophylline can inhibit phosphodiesterase, cAMP destruction reduced intracellular cAMP levels. Which in turn produces a physiological effect that reduces the release of histamine and the hypersensitive response slow-reacting substance (SRS-A), leading to relaxation of smooth muscle and bronchial