论文部分内容阅读
目的 :研究骨转移瘤患者骨密度和骨代谢状态的变化。方法 :采用双能 X线骨密度仪(DEXA)测量 2 0例骨转移瘤患者骨密度 (BMD) ,同时采用放射免疫法测定血清骨钙素 (BGP) , 型胶原羧基末端肽 (ICTP)水平 ,并与 2 0例正常人作对照。结果 :骨转移瘤组 L2 、L3、L4,右股骨颈 ,右Ward区和右大转子 BMD显著下降 (P<0 .0 5～ P<0 .0 0 1)。骨转移瘤组血清 BGP、ICTP显著升高 (P<0 .0 5～ P<0 .0 0 1)。结论 :骨转移瘤患者腰椎、髋部 BMD下降 ,血清 BGP、ICTP升高 ,骨转换增快。
Objective: To study the changes of bone mineral density and bone metabolism in patients with bone metastases. Methods: Bone mineral density (BMD) in 20 patients with bone metastases was measured by dual energy X-ray absorptiometry (DEXA). Serum BGP and ICTP levels were measured by radioimmunoassay , And compared with 20 normal controls. Results: BMD of L2, L3, L4, right femoral neck, right Ward area and right greater trochanter in bone metastases group decreased significantly (P <0.05 ~ P <0.01). Serum BGP and ICTP in bone metastases group were significantly increased (P <0.05 ~ P <0.01). Conclusion: The BMD of lumbar vertebrae and hip of patients with bone metastases decreased, serum BGP and ICTP increased, and bone turnover increased.