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本文观察新生儿休克30例。病死率为53.3%。休克组血浆内皮素(ET)浓度明显高于正常组(P=0.02)。血浆 ET 浓度与血 pH 值呈显著负相关(P=0.01,r=-0.45),PCO_2≥6.7kPa 组 ET浓度明显高于<6.7kPa 组(P<0.05),提示酸血症使血管内皮细胞受损可能是 ET 释放或合成增多的原因。抢救休克时及早纠正酸中毒维持内环境稳定是阻止病情发展的重要措施。收缩压<6.7kPa 组血浆 ET 浓度较>8.0kPa 组明显增高(P<0.05),血压下降是否与 ET 导致心脏功能障碍有关,尚有待研究。
This article observed 30 cases of neonatal shock. Case fatality rate was 53.3%. The level of endothelin (ET) in shock group was significantly higher than that in normal group (P = 0.02). Plasma ET concentration was negatively correlated with blood pH (P = 0.01, r = -0.45), and ET concentration in PCO_2≥6.7kPa group was significantly higher than that <6.7kPa group (P <0.05), suggesting that acidosis causes vascular endothelial cells Damage may be caused by increased ET release or synthesis. Early rescue of shock to correct acidosis to maintain the stability of the internal environment is an important measure to prevent the progression of the disease. The systolic blood pressure <6.7kPa group plasma ET concentration was significantly higher than the> 8.0kPa group (P <0.05), whether the decline in blood pressure and ET lead to cardiac dysfunction, remains to be studied.