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醋炔诺酮肟对实验动物有明显的抗着床作用。小鼠、大鼠和家兔在妊娠第2天起,分别给予醋炔诺酮肟0.5、1和2毫克/公斤,每天一次,连续3天,均有显著的抗着床作用。大鼠在妊娠第2或3天一次给醋炔诺肟酮5或10毫克/公斤,亦有明显的抗着床作用。家兔4只,每日灌服醋炔诺酮肟10毫克/公斤(约为临床剂量500倍),连续3周,给药后肝功能升高,停药2周后恢复正常,血象和肾功能均无明显变化。犬3只,每日灌服醋炔诺酮肟1～2毫克/公斤(约为临床剂量50～100倍),连服14个月,无明显毒性。
Acetoxynil oxime has obvious anti-implantation effects on experimental animals. Mice, rats and rabbits were administered with 0.5, 1 and 2 mg / kg of norethisterone oxime respectively on the 2nd day of gestation, once a day for 3 consecutive days with significant anti-implantation effect. Rats in the second or third trimester of gentamicin once every 5 or 10 mg / kg, also have significant anti-implantation effect. Four rabbits were drenched daily with a dose of 10 mg / kg of norethisterone oxime (about 500 times the clinical dose) for 3 consecutive weeks. After administration, liver function was elevated and returned to normal after 2 weeks of withdrawal. No significant changes in function. 3 dogs, daily dose of vinegar norethindrone oxime 1 ~ 2 mg / kg (about the clinical dose of 50 to 100 times), even for 14 months, no significant toxicity.