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目的研究青年代谢综合征(MS)与大肠息肉的相关性,分析青年人群息肉患病的高危因素,为青年人群结肠镜筛检提供参考。方法选择2010年1月至2014年12月在汕头市中心医院消化内镜中心行电子结肠镜检查年龄20~40岁的患者940例为研究对象,将电子结肠镜检查被确诊为大肠息肉并住院治疗的患者377例设为息肉组,未检出器质性疾病的人群563例设为对照组;并根据是否患有MS将940例分为MS患者233例,非MS者707例。用Excel表格收集每例研究对象的相关资料,包括性别、体质指数(BMI)、腰围、血压、空腹血糖(FPG)、甘油三酯(TG)及高密度脂蛋白胆固醇(HDL-C)。对息肉组和对照组患者MS各组分的差异进行比较,对息肉组患者MS各组分与息肉特征的相关性进行分析。结果在233例MS者中,患大肠息肉142例(60.9%),明显高于非MS者的大肠息肉患病率33.2%(235/707),差异有统计学意义(P<0.01)。息肉组与对照组的男女构成、BMI、腰围、收缩压、FPG、TG水平比较,差异均有统计学意义(P<0.05,P<0.01)。对377例大肠息肉患者的MS各组分与息肉特征的相关性分析结果显示,女性患者、高TG、低HDL-C者息肉好发于右结肠;息肉恶变率在收缩压≥140 mm Hg者和FPG≥6.1 mmol/L者中较高。结论青年男性、腰围较大,BMI、收缩压、FPG、TG较高者更易发生大肠息肉,要做好高危人群的监测。
Objective To study the correlation between metabolic syndrome (MS) and colorectal polyps in young people and to analyze the risk factors of polyps in young people and to provide a reference for colonoscopy screening of young people. Methods From January 2010 to December 2014, 940 patients aged 20-40 years old who underwent electronic colonoscopy at the digestive endoscopy center of Central Hospital of Shantou were enrolled. Electronoscopy was diagnosed as colorectal polyps and hospitalized A total of 377 patients were treated as polyp group and 563 patients without organic disease as control group. According to whether there were MS patients, 940 patients were divided into 233 MS patients and 707 non-MS patients. Data on each subject, including gender, body mass index (BMI), waist circumference, blood pressure, fasting blood glucose (FPG), triglycerides (TG) and high density lipoprotein cholesterol (HDL-C), were collected on an Excel spreadsheet. The differences of MS components between the polyps group and the control group were compared, and the correlation between MS components and polyps characteristics in patients with polyps was analyzed. Results Among 233 MS patients, 142 cases (60.9%) had colorectal polyps, which was significantly higher than that of non-MS patients (33.2%, 235/707). The difference was statistically significant (P <0.01). There were significant differences in the constitution of men and women, BMI, waist circumference, systolic blood pressure, FPG and TG between the polyp group and the control group (P <0.05, P <0.01). In 377 patients with colorectal polyps, the correlation analysis of MS components and polyp features showed that female patients with high TG, low HDL-C polyps occurred in the right colon; polypoid degeneration in patients with systolic blood pressure ≥ 140 mm Hg And FPG≥6.1 mmol / L were higher. Conclusion Young men, large waist circumference, BMI, systolic blood pressure, FPG, TG are more likely to occur colorectal polyps, to do the monitoring of high-risk groups.