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tsg101是近年被发现的一种肿瘤敏感基因,该基因在小鼠成纤维细胞中功能性敲除导致细胞转化形成裸鼠转移性肿瘤。这种效应可由tsg101功能的恢复而逆转,提示tsg101有抑制细胞恶性生长的功能。 作者用PCR、原位杂交等方法,证明人TSG101基因位于11号染色体短臂1区5带的1～2亚带(11p15.1-p15.2)。小鼠TSG101基因位于7号染色
Tsg101 is a tumor-sensitive gene discovered in recent years. Functional knock-out of this gene in mouse fibroblasts results in the transformation of cells into nude mice metastatic tumors. This effect can be reversed by the recovery of tsg101 function, suggesting that tsg101 inhibits the malignant growth of cells. The authors used PCR, in situ hybridization and other methods to prove that the human TSG101 gene is located in the 1-5 subbands (11p15.1-p15.2) of the 1st and 5th bands of the short arm of chromosome 11. Mouse TSG101 gene is located in the No. 7 staining