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目的建立Wistar大鼠脾虚症消化不良(NUD)动物模型,初步观察中药复方对该症的疗效。方法将30只Wistar大鼠分为空白对照组、模型组和中药治疗组。用蕃泻叶法制备脾虚症模型,用中药复方治疗,观察体重及外观变化,测定消化道排空速率和血浆胃动素。结果用蕃泻叶法可成功制备脾虚症动物模型;中药组动物的小肠推进率和血浆胃动素均较模型组有显著提高(P<0.01)。结论用蕃泻叶法可制备Wistar大鼠NUD症模型,中药复方对NUD症疗效显著。
Objective To establish a rat model of spleen deficiency dyspepsia (NUD) in Wistar rats and to observe the effect of traditional Chinese compound prescription on this disease. Methods Thirty Wistar rats were divided into blank control group, model group and traditional Chinese medicine treatment group. The spleen deficiency syndrome model was prepared with the Tuzi yep leaf method and treated with the traditional Chinese compound compound. Changes in body weight and appearance were observed, and the emptying rate of the digestive tract and plasma motilin were measured. Results The animal model of spleen deficiency syndrome could be successfully prepared by using Tudou lixivium method. The intestinal propulsive rate and plasma motilin of the Chinese herb group were significantly higher than those of the model group (P<0.01). Conclusion The Wistar rat model of NUD can be prepared by using Tuxede leaf method. The effect of Chinese compound prescription on NUD is significant.