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目的探讨唇腭裂（CLP）的发病原因。方法采用1：1配对的方法，对90例唇腭裂患儿的母亲与非唇腭裂患儿的母亲进行了对照研究，调查范围包括母亲自身危险因素和环境中的危险因素两大方面。结果在所列的7种因素中，有6种因素表现出较高的危险度，依其危险度（OR值）大小排列为：孕期接触工业毒物（9．0），孕期使用某些化学药物（8.0），家中饲养猫、狗等宠物（6．0），父母近亲结婚（6．0），孕期内受病毒感染（4．5）和孕期内喷洒农药除草剂（4．0）。结论孕期内接触有害物质是CLP的重要致病因素。
Objective To investigate the pathogenesis of cleft lip and palate (CLP). Methods A one-to-one pairing method was used to compare 90 mothers with non-cleft lip and palate mothers in 90 children with cleft lip and palate. The investigation included two aspects: the mother’s own risk factors and the environment’s risk factors. Results Of the seven listed factors, six showed high risk, ranked according to their risk (OR) size: exposure to industrial toxicants during pregnancy (9.0), use of certain chemical drugs during pregnancy (8.0), pets such as cats and dogs (6.0), parents’ close relative’s marriage (6.0), virus infection during pregnancy (4.5) and pesticide herbicide during pregnancy (4.0). Conclusions Exposure to harmful substances during pregnancy is an important risk factor for CLP.