【摘 要】
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最近在维也纳举行的欧洲医疗肿瘤学协会(ESMO)会议上发表的CORE研究结果表明,选择性雌激素受体调节剂雷洛昔芬(raloxifene,Evista)可能比惟一批准的现有乳腺癌预防药他莫昔芬
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最近在维也纳举行的欧洲医疗肿瘤学协会(ESMO)会议上发表的CORE研究结果表明,选择性雌激素受体调节剂雷洛昔芬(raloxifene,Evista)可能比惟一批准的现有乳腺癌预防药他莫昔芬(tamoxifen)更安全有效。 MORE和CORE两项研究的综合结果显示,经过8a治疗,雷洛昔芬发生浸润性乳腺癌的风险率比安慰剂下降 66％(风险比0．34,95％可信限0．22-0．50),比他莫昔芬减
The CORE study, presented at the recent meeting of the European Association of Medical Oncology (ESMO) in Vienna, showed that the selective estrogen receptor modulator raloxifene (Evista) may be less effective than the only approved current breast cancer prophylaxis Tamoxifen is safer and more effective. The combined results of the MORE and CORE studies showed that the risk of invasive rallying cancer with raloxifene was 66% lower than placebo after 8 months of treatment (hazard ratio 0.34, 95% confidence limit 0.22-0 .50), less than tamoxifen
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