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目的对氟喹诺酮类药物在临床上的应用情况进行分析探讨,为今后的临床合理用药提供可靠的参考依据。方法抽取在2008年1月至2012年12月间本院收治的接受抗菌药物进行治疗的临床患者病例986例,对其临床资料展开回顾性分析,统计喹诺酮类药物的应用情况。结果本组986例患者中有46.04%患者应用了喹诺酮类药物,其中以左氧氟沙星的使用率最高;有90.97%的患者为联合用药;不合理用药者占8.81%;发生不良反应者占5.07%。结论临床上喹诺酮类药物应用广泛,然而存在一定不合理使用现象和不良反应发生率,因此在用药过程中应严格掌握用药指征,避免发生不良反应。
Objective To analyze and discuss the clinical application of fluoroquinolones in order to provide a reliable reference for clinical rational drug use in the future. Methods A total of 986 cases of clinical patients admitted to our hospital from January 2008 to December 2012 were enrolled in this study. The clinical data were retrospectively analyzed and the application of quinolones was statistically analyzed. Results In this group, 46.04% of the 986 patients were treated with quinolones, among which levofloxacin was the most frequently used drug. 90.97% of the 986 patients were combined with those with unreasonable use of drugs and 8.81% with adverse reactions, while 5.07% with adverse reactions. Conclusion Quinolones are widely used clinically, however, there are some phenomena of unreasonable use and incidence of adverse reactions. Therefore, medication indications should be strictly controlled in the course of medication to avoid adverse reactions.