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目的:通过回顾已有的文献资料,了解我国婚检政策变动前后出生缺陷发生率的变化,说明婚前检查对防止出生缺陷的作用。方法:采用Meta分析的方法,将2002年和2003年的出生缺陷数和围产儿数分别合并后得出的出生缺陷率作为对照组,与2005~2008年的合并出生缺陷率进行比较,采用Stata 11.0软件的Meta分析模块进行统计分析。结果:Meta分析表明,取消强制婚检后2005~2008年合并出生缺陷率是取消前2002年和2003年合并出生缺陷率的1.32倍(D+L pooled RR=1.32,95%CI:1.13~1.53)。结论:取消强制婚检后,我国出生缺陷率有所上升。出生缺陷会对青年男女的生理、心理、家庭和经济层面产生负面影响,婚前检查对促进青年生殖健康和身心和谐有重要意义。
Objective: To review the existing literature to understand the changes in the prevalence of birth defects before and after the premarital premarital examination in our country, and to explain the effect of premarital examination on preventing birth defects. Methods: Meta-analysis method was used to compare the birth defects rate of the combined birth defects and perinatal births in 2002 and 2003 respectively as a control group, compared with the combined birth defect rate from 2005 to 2008, Stata 11.0 software Meta analysis module for statistical analysis. Results: Meta-analysis showed that the combined birth defect rate from 2005 to 2008 after the abolition of compulsory premarital examination was 1.32 times of the combined birth defect rate before 2002 and 2003 (D + L pooled RR = 1.32, 95% CI: 1.13-1.53) . Conclusion: After the abolishment of forced premarital examination, the birth defect rate in our country has risen. Birth defects have a negative impact on the physical, psychological, family and economic aspects of young men and women. Premarital examination is important for advancing youth reproductive health and physical and mental harmony.