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丙型肝炎病毒(hepatitis C virus,HCV)的细胞入侵过程由多因素介导,包括多种受体及触发病毒内吞入胞的细胞因素。新发现的受体分子occludin已被证明与SR-B1、CD81、claudin同介导HCV细胞入侵,occludin和claudin同为组成细胞间紧密连接的整合蛋白,引起了研究者们对紧密连接及细胞极性对HCV入侵影响的广泛关注。对细胞极性及紧密连接的研究,有助于发现新的HCV治疗药物的作用靶点,从而干预其细胞入侵及细胞间蔓延。本文从肝细胞极性特点、紧密连接及主要整合蛋白claudin和occludin、极性细胞模型及与HCV入侵的关系等几个方面综述了近来的最新进展。
Cellular invasion of hepatitis C virus (HCV) is mediated by multiple factors, including multiple receptors and cytokines that trigger endocytosis of the virus. The newly discovered receptor molecule occludin has been shown to mediate the invasion of HCV cells with SR-B1, CD81 and claudin. Occludin and claudin are integral proteins that form tight junctions between cells, which have led researchers to investigate the tight junction and cell polarity The widespread concern about the impact of sex on HCV invasion. Research on cell polarity and tight junctions can help find new targets for HCV therapies that intervene in cell invasion and cell-cell spread. This review summarizes recent advances in hepatocyte polarity, tight junctions and the major integrins claudin and occludin, the relationship between polar cell models and HCV invasion.