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目的观察马来酸曲美布汀联合谷维素对肠易激综合征的治疗效果。方法将2009年1月至2011年1月收治的198例肠易激综合征患者随机分为两组,其中治疗组110例,给予马来酸曲美布汀联合谷维素进行治疗;常规组88例,给予氟西汀联合谷维素进行治疗,观察两组患者治疗后的临床疗效。结果治疗组总有效率为90.00%,高于常规组的72.73%,两组治疗效果比较差异有统计学意义(P<0.05)。结论马来酸曲美布汀联合谷维素对胃肠兴奋、抑制的双向运动和内脏自主神经系统起调节作用,并减缓了患者的症状,对其康复起了很大的推动作用。
Objective To observe the therapeutic effect of trimebutine maleate and oryzanol on irritable bowel syndrome. Methods A total of 198 IBS patients treated from January 2009 to January 2011 were randomly divided into two groups, 110 in the treatment group and Trimebutine maleate plus oryzanol for treatment. In the conventional group, 88 , Fluoxetine combined with oryzanol for treatment, observation of two groups of patients after treatment of clinical efficacy. Results The total effective rate of the treatment group was 90.00%, which was higher than that of the conventional group (72.73%). The difference between the two groups was statistically significant (P <0.05). Conclusion Trimebutine maleate combined with oryzanol exerts a regulative effect on gastrointestinal excitability and inhibition of bidirectional movement and visceral autonomic nervous system, alleviates the symptoms of patients and plays a significant role in promoting the recovery.