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近年来,单克隆抗体技术已被广泛应用于医学科学的各个领域。关于单克隆抗体的技术问题及其在肿瘤、细胞免疫和移殖等方面的应用,国内已有报道。本文仅将单克隆抗体在病毒学中的应用情况加以介绍。一、病毒学研究 (一)流感病毒由甲型流感病毒引起的疾病长期以来一直为人们所关注。由于其抗原性易发生变异,往往造成局部地区,以至世界性的大流行。与抗原性变异有关的分子主要是流感病毒表面的血凝素(HA)和神经氨酸酶(NA),其中HA具有更重要的意义。多年来,人们为了搞清流感病毒抗原漂移和转变的机理,已在研究HA的抗原性方面做了大量工作。但以往研究HA抗原性的方法有一些缺点,
In recent years, monoclonal antibody technology has been widely used in various fields of medical science. On the technical problems of monoclonal antibodies and its application in tumor, cell immunity and transplantation, has been reported in China. This article only the monoclonal antibody in the application of virology to be introduced. First, the virological research (A) Influenza virus Influenza A virus caused by the disease has long been of concern. Due to its antigenic variation prone to, often resulting in some areas, and the world’s pandemic. The molecules involved in antigenic variation are mainly hemagglutinin (HA) and neuraminidase (NA) on the surface of influenza virus, of which HA is more important. Over the years, in order to understand the mechanism of influenza virus antigen drift and transformation, a great deal of work has been done on the antigenicity of HA. However, there are some shortcomings in the previous study of HA antigenicity,