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ＩＣＲ小鼠腹腔接种伯氏疟原虫ＡＮＫＡ株后２ｄ全部出现原虫血症。感染后２—７ｄ进行检测：每１００个淋巴细胞含疟原虫数从２．３±１．３×１０３升至９３．７±１．８×１０３个。红细胞数在ｄ２从８．２±０．９×１０１２／Ｌ升至１１．１±１．０×１０１２／Ｌ，随后持续下降，至ｄ７为１．９±０．４×１０１２／Ｌ，白细胞计数波动；红细胞Ｃ３ｂ受体花环率和红细胞免疫复合物花环率除感染后２ｄ上升外，随后持续下降至极低水平；感染鼠血清中红细胞免疫促进因子活性下降，抑制因子活性有所增强。结果提示感染疟原虫后，小鼠红细胞免疫功能明显下降，这可能不仅与红细胞膜受损有关，而且与血清中红细胞免疫调节因子活性改变有关。
2 days after ICR mice were inoculated intraperitoneally with Plasmodium berghei ANKA strain, parasitemia was observed. 2-7d after infection were tested: the number of Plasmodium per 100 lymphocytes increased from 2.3 ± 1.3 × 103 to 93.7 ± 1.8 × 103. The number of erythrocytes increased from 8.2 ± 0.9 × 1012 / L to 11.1 ± 1.0 × 1012 / L at d2, then decreased continuously to 1.9 ± 0.4 × 1012 / L for d7, Count fluctuating; the rate of erythrocyte C3b rosette and erythrocyte immune rosette rose except for 2d after infection, then continued to decrease to extremely low level; the activity of erythrocyte immunoregulatory factor decreased and the inhibitory activity increased in infected rat serum. The results suggest that the infection of erythrocytes in mice significantly decreased after infection with Plasmodium, which may be related to not only the damage of erythrocyte membrane but also the activity of erythrocyte immunoregulatory factor in serum.