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目的对乙型肝炎病毒e抗原(Hepatitis B e antigen,HBeAg)阴性慢性乙型肝炎(chronichepatitis B,CHB)患者的临床特征及转归进行随访。方法前瞻性地观察93例HBeAg阴性慢性乙型肝炎患者(9·4±6·9)年,对患者的临床特征及转归进行研究。结果93例患者多数平均随访9·4年,23·66%发展成肝硬化,6·45%发生原发性肝癌,4·30%死亡。通过单因素分析表明年龄、是否有嗜酒史、ALT活动形式与HBeAg阴性慢性乙型肝炎患者发生肝硬化和原发性肝癌的比例相关,差异有统计学意义。结论HBeAg阴性乙型肝炎患者平均随访9·4年转归不佳。年龄、是否有嗜酒史、ALT活动形式与HBeAg阴性慢性乙型肝炎患者发生肝硬化和原发性肝癌相关。
Objective To investigate the clinical characteristics and prognosis of patients with hepatitis B virus (HBeAg) -related chronic hepatitis B (CHB). Methods A total of 93 patients with HBeAg-negative chronic hepatitis B (9.4.4 ± 6.9) years were prospectively studied. The clinical characteristics and outcome of the patients were studied. Results The 93 patients were followed up for an average of 9.4 years, 23.66% developed cirrhosis, 6.45% developed primary liver cancer and 4.30% died. By univariate analysis showed that age, whether there is alcohol history, ALT activity and HBeAg-negative chronic hepatitis B patients with cirrhosis and primary liver cancer rate was significantly different. Conclusion The average HBeAg-negative hepatitis B patients were followed up for a poor prognosis in 9.4 years. Age, whether there is a history of alcoholism, ALT activity in patients with cirrhosis and primary liver cancer associated with HBeAg-negative chronic hepatitis B patients.