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目的对深圳东部地区本地居民、外来人群进行地中海贫血的调查研究。方法采用日本SysmexSE-9000全自动血细胞分析仪,运用红细胞脆性一管定量法和血红蛋白电泳初筛法,对可疑阳性标本进行α-地中海贫血基因分析和β-地中海贫血基因分析。结果本地居民350人,异常基因携带者36例,其中β-地中海贫血异常基因12例,α-地中海贫血异常基因23例,双重杂合者1例,发病率10.28%。外来人群349人,异常基因携带者4例,β-地中海贫血异常基因1例,α-地中海贫血异常基因3例,发病率1.14%。结论本地居民发病率比外来人群发病率高9倍。
Objective To investigate the survey of thalassemia in local residents and migrants in the eastern part of Shenzhen. Methods The SysmexSE-9000 automatic hematology analyzer was used in Japan. The gene of α-thalassemia and β-thalassemia gene were analyzed in suspicious positive samples by the method of quantitative determination of erythrocyte fragility and hemoglobin electrophoresis. Results There were 350 local residents and 36 patients with abnormal gene carriers. Among them, 12 cases of β-thalassemia abnormal gene, 23 cases of α-thalassemia abnormal gene and 1 case of double heterozygote, the incidence rate was 10.28%. 349 foreign population, 4 carriers of abnormal gene carriers, 1 case of β-thalassemia abnormal gene and 3 cases of α-thalassemia abnormal gene, the incidence rate was 1.14%. Conclusion The incidence of local residents than the incidence of foreign population 9 times higher.