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目的观察氯沙坦合用苯那普利对慢性肾脏病保护作用。方法治疗组50例慢性肾炎患者应用氯沙坦合用苯那普利和对照组30例慢性肾炎患者应用依那普利前及应用8周后血钾、钠、氯、24h尿蛋白定量、血尿素氮、肌酐、血促红细胞生成素情况进行观察,应用卡方检验法统计比较上述各因素前后变化。结果治疗组应用氯沙坦合用苯那普利8周后,血钾、钠、氯、血促红细胞生成素无明显变化,统计学无显著差异,24h尿蛋白定量则显示减少,血尿素氮、肌酐、统计学有显著差异。结论氯沙坦合用苯那普利对慢性肾病肾功能有一定保护作用,而对照组应用依那普利统计学无差异。
Objective To observe the protective effect of losarnan combined with benazepril on chronic kidney disease. Methods 50 cases of chronic nephritis patients treated with losartan benazepril and the control group of 30 patients with chronic nephritis before enalapril and application of 8 weeks after potassium, sodium, chlorine, 24h urinary protein, blood urea nitrogen , Creatinine, erythropoietin were observed, the use of chi-square test statistics before and after comparison of the above changes. Results After treatment with losartan and benazepril for 8 weeks, serum potassium, sodium, chloride and blood erythropoietin did not change significantly, and there was no significant difference between the two groups. The urinary protein excretion in 24h after treatment was decreased and blood urea nitrogen, Creatinine, statistically significant differences. Conclusion Losartan combined with benazepril on renal function in patients with chronic kidney disease have a protective effect, while the control group no difference in the use of enalapril statistics.