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自从25年前口服避孕药(OC)问世以来,已证实心血管疾病与孕激素的含量有关。使用OC19-去甲基睾丸酮(特别是18-甲基炔诺酮)妇女的血浆中高密度脂蛋白-胆固醇(HDL-C)降低,性激素结合球蛋白发生变化。血浆中HDL-C和心血管疾病(血栓形成,中风和心肌梗塞)相关已为美国Framinghan大量研究证实。新一代的孕激素:Desogestrel是由Organon公司科研实验室研制成功的第一种新一代孕激素避孕药,无雌激素活性,但有明显的孕激素活性并有强烈的拮抗雌激素活性的作用。这是一种极为可
Since the advent of oral contraceptives (OCs) 25 years ago, it has been shown that cardiovascular disease is associated with progestin levels. In women with OC19-nor-methyl testosterone (especially 18-norgestrel), there is a reduction in high-density lipoprotein-cholesterol (HDL-C) and a change in sex hormone-binding globulin. The correlation between plasma HDL-C and cardiovascular disease (thrombosis, stroke, and myocardial infarction) has been confirmed by numerous studies in Framinghan, USA. A new generation of progesterone: Desogestrel is the first new generation of progestin contraceptives successfully developed by Organon Scientific Research Laboratory. It has no estrogenic activity but obvious progestogenic activity with a strong antagonistic effect on estrogenic activity. This is a very acceptable