论文部分内容阅读
九十年代以来,人们发现体内有一类异构前列腺素F_(2α)(PaF_(2α)),这类物质与一般的前列腺素不同,是花生四烯酸另一代谢途径——氧自由基催化的脂质过氧化产物,不依赖于环氧化酯,其中最主要的成份是8—表氧—PGF_(2α)。一些研究资料表明,异构前列腺素是脂质过氧化反应一种新的特异性灵敏指标。糖尿病并发动脉粥样硬化的发生和发展与氧自由基、脂质过氧化密切相关。国外均用气相色谱质谱方法测定异构前列腺素,无法在临床推广应用。王兆銊等1996年首先建立了血浆异构前列腺素的ELISA方法后,近又建立了放射免疫分析法(RIA)。本文观察了糖尿病伴动脉硬化患者的异构前列腺素浓度变化和脂质过氧化物水平变化,现将结果报告如下。
Since the nineties, it has been found that there is a class of isoforms of prostaglandin F 2α (PaF 2α), which are different from other prostaglandins and are catalyzed by oxygen free radicals Of the lipid peroxidation products, independent of the epoxidized ester, the most important of which is 8-epoxidized-PGF 2α. Some research data show that isoprostaglandins lipid peroxidation is a new type of specific sensitivity indicators. The occurrence and development of diabetic concurrent atherosclerosis are closely related to oxygen free radicals and lipid peroxidation. Foreign countries are using GC-MS method for the determination of isoprostane prostaglandins, can not be in clinical application. Wang Zhaoyu et al first established in 1996, plasma isoprostaglandin ELISA method, the establishment of a radioimmunoassay (RIA). This article observed changes in patients with diabetes with arteriosclerosis heterogeneous prostaglandin concentration and lipid peroxide levels, the results are reported below.