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喉腔及喉咽部原发性恶性黑色素瘤极为罕见。1985年～1997年8月,共收治喉腔、喉咽部粘膜原发性恶性黑色素瘤各2例,肿瘤多伴有溃疡并缺乏色素,临床表现为声音嘶哑、吞咽困难、咯血、咽部不适等,易与该部位常见的鳞状细胞癌相混淆。其中完整详实的病史、全面彻底的体格检查可提供重要的诊断依据,免疫组化病理有助确诊。大范围彻底的手术切除、根治性颈淋巴结清扫术可作为局限性原发病变的首选治疗。对术后可疑残留病变,可辅以放疗或化疗。
Primary throat and larynx malignant melanoma is extremely rare. From 1985 to August 1997, a total of 2 cases of primary malignant melanoma of the larynx and hypopharynx were treated. The tumors were often accompanied by ulceration and lack of pigment. The clinical manifestations were hoarseness, dysphagia, hemoptysis and throat discomfort Etc., easily confused with the common squamous cell carcinoma of the site. One complete and detailed medical history, a thorough examination of the body can provide an important basis for diagnosis, immunohistochemical diagnosis is helpful. A wide range of radical surgical resection, radical neck dissection can be used as the primary treatment of localized primary disease. Suspected residual disease after surgery, supplemented by radiotherapy or chemotherapy.