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间质细胞衰老、上皮细胞转分化(EMT)关系密切,两者也与恶性肿瘤关系密切,间质细胞衰老产生多样化的趋化因子以及细胞因子,最终改变微环境,通过旁分泌等作用,促进EMT,EMT持续进展会引起结构改变,多种因素共同作用导致上皮细胞癌变。同一个因子(如Twist、ZEB1等)或信号通路可能在EMT及间质细胞衰老相互拮抗事件中发挥重要作用,在某一个阶段,起到同时促进作用,促进上皮-间质转化同时引起衰老,MET、间质细胞衰老共同调节细胞内外环境信号,诱导癌变。
Interstitial cell senescence, epithelial cell transdifferentiation (EMT) are closely related, both are also closely related to malignant tumors, interstitial senescence produce a variety of chemokines and cytokines, and ultimately change the microenvironment, through the role of paracrine, Promote the EMT, EMT continued to progress will cause structural changes, a combination of factors lead to carcinogenesis of epithelial cells. The same factor (such as Twist, ZEB1, etc.) or signaling pathway may play an important role in EMT and stromal cell senescence mutual antagonism event, at a certain stage, while promoting the role of promoting epithelial-mesenchymal transition at the same time cause aging, MET, interstitial cell senescence jointly regulate intracellular and extracellular signal, induce cancer.