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目的观察比较辛温归肺经(豆蔻、紫苏叶、白芷)与辛凉归肺经(薄荷、菊花、前胡)中药对复合因素致肺阳虚大鼠的影响。方法采用烟熏(外邪犯肺)+冰水游泳(形寒劳倦)+服用冰水(内饮生冷)三因素复合造成肺阳虚大鼠模型。造模同时灌胃给予豆蔻、紫苏叶、白芷、薄荷、菊花、前胡水提取物,连续38 d。观察大鼠一般行为学,测量体重、肛温、背温、抓力;末次给药后气管插管毛细玻管法测定排痰量;取血测定血清NO、血液学及血液流变学指标;解剖取心、肺、肝、肾、脾,测脏器系数。结果①辛温归肺经的豆蔻、紫苏叶及白芷能提高肺阳虚大鼠体重、肛温、背温、抓力、血白细胞水平,减少痰量、血清NO、血液黏度、心系数、肺系数、脾系数、肾系数,说明豆蔻、紫苏叶及白芷性味归经相同(同属辛温归肺经),表现出相近的药理作用,通过辛温入肺从而改善形体消瘦、阳虚内寒、背畏寒、体倦乏力、痰涎清稀、肺血亏虚及瘀滞等。②辛凉归肺经的薄荷、菊花及前胡能提高体重、血白细胞水平,降低肝系数;薄荷、前胡还能减少痰量、血液黏度,说明薄荷、菊花及前胡同属辛凉归肺经,也表现出相近的药理作用,通过辛入肺而改善形体消瘦、肺血亏虚及瘀滞、痰涎清稀等。但因其性凉,对肺阳虚证之阳虚内寒、背畏寒等的改善作用不明显。结论性味归经相同的中药表现出相近或相同的药理作用;辛温归肺经、辛凉归肺经中药虽然味辛、作用部位在肺经,但因其性不同,药理作用仍有较大差异。该研究证明了相同味归经中药之间的药效相近,而相同味归经不同性的中药则相关指标作用相反。
Objective To observe and compare the effects of Xinwengui Pulmonary Meridian (Cardamom, Perilla frutescens, Angelica dahurica) and Xinlianggui Pulmonary Meridian (Peppermint, Chrysanthemum and Peucedanum) on Pulmonary Yang Deficiency in Rats. Methods The model of lung-yang deficiency was induced by the combination of smoking (exogenous evil offender lung) + ice-water swimming (cold-tiredness) + taking ice water (cold drinking). Simultaneously, cardamom, perilla leaf, Angelica dahurica, peppermint, chrysanthemum and exuviate water extract were given intragastrically for 38 days continuously. Observed the general behavior of rats, body weight, rectal temperature, back pain, gripping force; the last administration after tracheal intubation capillary tube method for the determination of sputum volume; blood to determine serum NO, hematology and hemorheology indicators; Anatomical coring, lung, liver, kidney, spleen, measuring organ coefficient. Results ①Xamenopus xerophyllum, cardamom, and Angelica dahurica could improve body weight, rectal temperature, blood pressure, blood pressure, blood leukocyte, sputum volume, serum NO, blood viscosity, Lung coefficient, spleen coefficient, kidney coefficient, indicating the cardamom, basil leaves and Angelica Angelica by the same (all belong to Simvastatin lung), showing similar pharmacological effects, through the Xin temperature into the lungs to improve the body weight loss, yang Chill, back chills, body fatigue, phlegm clear thin, pulmonary blood deficiency and stasis. ② Xinliang to the lung through the mint, chrysanthemum and Qianhu can increase body weight, blood leukocyte levels, reduce the liver coefficient; peppermint, Peucedanum can reduce the amount of sputum, blood viscosity, indicating that mint, chrysanthemum and the former alley is Xinlianggui lung After, also showed similar pharmacological effects, by Xin into the lungs to improve the body weight loss, pulmonary blood deficiency and stasis, sputum Qinglie and so on. However, due to its cold, Yang deficiency of lung Yang deficiency cold, dizziness and other improvement is not obvious. Conclusions The taste of the same Chinese medicine through the same or similar pharmacological effects; Xin Wen Gui lung, Xin Liang Gui lung by the traditional Chinese medicine though spicy, the role of the site in the lung, but because of their sexuality, the pharmacological effects are still more Big difference. The study proved similar efficacy of traditional Chinese medicine between the similar efficacy, while the same taste through the different Chinese medicine is the opposite of the relevant indicators.