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对82例幽门螺杆菌(HP)阳性的十二指肠溃疡用雷尼替丁、羟氨苄青霉素和甲硝唑三联疗法2周,追踪1年,并与145例铋剂三联疗法病例对照。结果治疗组溃疡愈合率87.8%,HP根除率89.0%;对照组两参数为92.4%和85.7%(P均＞0.05)。治疗组副反应显著少。追踪1年,治疗组HP感染再燃9例(12.3%),重感染2例(2.7%),溃疡复发率HP阴转组1/61(1.6%),HP阳性组7/11(63.6%)(P＜0.01)。因再燃率高且在停药后4~8周发生,建议修定HP根除的标准时间,应从4周末延到8周末。
Eighty-two H. pylori-positive duodenal ulcers were treated with ranitidine, amoxycillin, and metronidazole for two weeks, followed up for 1 year and compared with 145 bismuth triple therapy cases. Results The healing rate of the ulcer in the treatment group was 87.8%, and the eradication rate of HP was 89.0%. The two parameters in the control group were 92.4% and 85.7%, respectively (all P> 0.05). Side effects were significantly less in the treatment group. After one year of follow-up, there were 9 cases (12.3%) of HP infection in treatment group and 2 cases (2.7%) of severe infection. The recurrence rate of ulcer was 1/61 (1.6%) in HP- (P <0.01). Due to the high reburning rate and 4-8 weeks after discontinuation, it is recommended to revise the standard time of HP eradication should be extended from the end of 4 weeks to 8 weeks.