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目的 探索p5 3、k ras基因同时突变对直肠癌的恶性行为升级的作用及其临床意义。方法 用PCR SSCP方法检测直肠癌细胞p5 3、K ras基因突变 ,分析该基因突变与临床病理因素及预后的关系。结果 直肠癌细胞p5 3、K ras基因突变与临床病理因素无关 ,生存率也无统计学差异。结论 直肠癌细胞p5 3、K ras基因突变对癌细胞恶性生物学行为升级无明显的促进作用 ,p5 3、K ras基因同时突变也无协同促癌作用 ,也不影响病人的预后。
Objective To explore the role and clinical significance of simultaneous mutation of p5 3 and k ras genes in malignant behavior of rectal cancer. Methods PCR SSCP was used to detect the mutation of p5 3 and K ras gene in rectal cancer cells. The relationship between the mutation and clinicopathological factors and prognosis was analyzed. Results The mutation of p5 3 and K ras in rectal cancer cells had no relationship with clinicopathological factors, and there was no significant difference in survival rate. Conclusions Mutations of p5 3 and K ras gene in rectal cancer cells have no obvious effect on the promotion of malignant biological behavior of cancer cells. There is no synergistic effect of p5 3 and K ras gene mutations in cancer promotion and prognosis.