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抗反转录病毒治疗(ART)开始的时机越来越早,但总有免疫重建失败或者Ⅰ型艾滋病病毒(HIV-1)潜伏感染灶无法清除的情况,因此白介素-2(IL-2)目前被广泛研究用于辅助ART治疗、加强免疫重建或者活化潜伏感染的HIV-1。目前比较确定的是:(1)IL-2能延长CD4+T细胞的半衰期,增加CD4+T细胞的数量;(2)IL-2合并ART与单独使用ART相比,不能减少HIV-1相关的机会性感染或死亡,临床应用着重于活化HIV-1储存库细胞;(3)IL-2合并ART能有效增加HIV-1储存库细胞的消减速率,外周循环中HIV-1感染的处于静止状态的记忆T细胞数量下降,甚至检测不出来;(4)IL-2的临床应用趋向周期性使用和长期使用。
Anti-retroviral therapy (ART) is beginning to start more and more early, but there are always cases of immune reconstruction failure or latent infection with type I HIV-1 (HIV-1) that can not be cleared. Interleukin-2 It has been extensively studied to aid in the treatment of ART, to enhance immune reconstitution, or to activate latent infection with HIV-1. At present, it is quite certain that: (1) IL-2 prolongs the half-life of CD4 + T cells and increases the number of CD4 + T cells; (2) IL-2 incorporation does not reduce HIV-1 relative to ART alone (3) IL-2 combined with ART can effectively increase the rate of cell depletion in HIV-1 repertoire, and the HIV-1 infection in the peripheral circulation is at a standstill State of memory T cells decreased, or even undetectable; (4) clinical application of IL-2 tends to be cyclical and long-term use.