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目的:探讨持续气道正压通气(CPAP)治疗对中重度阻塞性睡眠呼吸暂停综合征(OSAS)患者血液流变学的影响。方法:选择经多导睡眠监测确诊的中重度OSAS患者96例,于CPAP治疗前行全血粘度及红细胞比容检测,然后进行CPAP治疗3个月,治疗后再次行睡眠呼吸监测,全血粘度及红细胞比容检测,判断CPAP治疗对中重度OSAS患者的血液流变学有无影响。结果:OSAS患者经CPAP治疗后睡眠呼吸暂停指数显著降低,睡眠时平均及最低血氧饱和度显著增高(P<0.01)。OSAS患者经CPAP治疗后全血粘度及红细胞比容较治疗前显著降低(P<0.01)。结论:CPAP治疗可能通过改善OSAS患者的血液流变学异常,因而可降低OSAS患者发生心脑血管疾病的危险性。
Objective: To investigate the effect of continuous positive airway pressure (CPAP) on hemorheology in patients with moderate-severe obstructive sleep apnea syndrome (OSAS). Methods: Ninety-six patients with moderate-severe OSAS diagnosed by polysomnography were enrolled in this study. Whole blood viscosity and hematocrit were measured before CPAP treatment and then CPAP for 3 months. After the treatment, sleep apnea monitoring, whole blood viscosity And hematocrit test to determine whether CPAP treatment of moderate to severe OSAS patients with hemorheology have no effect. Results: The index of sleep apnea was significantly decreased after CPAP treatment in OSAS patients, and the mean and minimum oxygen saturation during sleep were significantly higher (P <0.01). The whole blood viscosity and hematocrit of patients with OSAS after CPAP treatment were significantly lower than those before treatment (P <0.01). Conclusion: CPAP may reduce the risk of cardiovascular and cerebrovascular diseases in OSAS patients by improving the hemorheological abnormalities in OSAS patients.