论文部分内容阅读
本文报道木桔根甲醇提取物（ＭＥＲＡ）及其化学成分对小鼠在体和离体肝脏组织或胞液（ｃｙｔｏｓｏｌ）脂质过氧化的抑制作用。ＭＥＲＡ能够明显增加肝细胞中超氧化物岐化酶和谷胱甘肽过氧化物酶的活性，而对过氧化氢酶活性的影响无统计学意义。其主要成分之一４－甲氧基－１－甲基－２－喹诺酮（ＭＭＱ）有升高ＦｅＣｌ２－抗坏血酸（ＡＡ）－ＡＤＰ中毒小鼠肝细胞中ＳＯＤ活性的作用。从木桔根分离出的各类化合物对离体条件下ＦｅＣｌ２－抗坏血酸，ＣＣｌ４－ＮＡＤＰＨ和ＡＤＰ－ＮＡＤＰＨ等自由基发生系统诱导的大鼠肝细胞中脂质过氧化物质形成有程度不同的抑制作用。在受试化合物中，ＭＭＱ和其衍生物花椒喹诺酮（ｉｎｔｅｇｒｉｑｕｉｎｏｌｏｎｅ）对上述三种自由基发生系统引起的脂质过氧化有较强的抑制作用；在选定的浓度下，其作用与（－生育酚（维生素Ｅ）的效果类同
This paper reports the inhibition of lipid peroxidation of liver tissue or cytosol in vivo and in vitro by methanolic root extract (MERA) and its chemical constituents. MERA significantly increased the activities of superoxide dismutase and glutathione peroxidase in hepatocytes, but the effect on catalase activity was not statistically significant. One of its main components, 4-methoxy-1-methyl-2-quinolones (MMQ), has the effect of increasing SOD activity in liver cells of FeCl2-ascorbic acid (AA)-ADP-intoxicated mice. The compounds isolated from the roots of Cinnamomum niger showed different degrees of inhibition of lipid peroxide formation in rat hepatocytes induced by free radical system such as FeCl2-ascorbic acid, CCl4-NADPH and ADP-NADPH under ex vivo conditions. . Among the tested compounds, MMQ and its derivative integrinquinolone have a strong inhibitory effect on lipid peroxidation caused by the above three free radical generating systems; at selected concentrations, its effect is related to (-fertility) The effect of phenol (vitamin E) is similar