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目的:分析帕罗西汀对脑卒中后抑郁患者的抑郁状态及神经功能恢复的影响。方法:将2011年5月-2013年10月收治的脑卒中后抑郁患者73例随机分为治疗组(40例)和对照组(33例),治疗组以帕罗西汀治疗,对照组以丙米嗪治疗,比较两组患者抑郁状态及神经功能恢复情况。结果:两组患者治疗前后加拿大神经功能评分量表(CNS)、汉密尔顿抑郁量表(HAMD)评分比较差异有统计学意义(P<0.05);治疗组不良反应发生率为2.5%,对照组不良反应发生率为21.2%,组间比较差异有统计学意义(P<0.05)。结论:帕罗西汀可有效减轻脑卒中后抑郁患者的抑郁状态,恢复神经功能,安全有效。
OBJECTIVE: To analyze the effect of paroxetine on depression and neurological recovery in patients with post-stroke depression. Methods: Seventy-three patients with post-stroke depression who were admitted from May 2011 to October 2013 were randomly divided into treatment group (40 cases) and control group (33 cases). The treatment group was treated with paroxetine, Azine treatment, depression and neurological recovery were compared between the two groups. Results: There were significant differences in CNS and HAMD before and after treatment between the two groups (P <0.05). The incidence of adverse reactions in the treatment group was 2.5%, while that in the control group was not good The response rate was 21.2%, there was significant difference between the two groups (P <0.05). Conclusion: Paroxetine can effectively relieve the depression of patients with post-stroke depression and restore neurological function, which is safe and effective.