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从临床分离获得口腔常见厌氧菌,除非脆弱类杆菌4株外,其余消化球菌及链球菌14株,革兰氏阳性无芽胞杆菌4株,以及需氧及兼性厌氧菌α-溶血链球菌4株对青霉素V敏感,MIC_(50)为≤0.06～0.125mg/L,MIC_(90)为0.125～0.25mg/L,急性牙周及根尖周感染患者的临床症状,白细胞总数和中性粒细胞分类计数在服用青霉素V后3天明显改善和好转。实验结果表明除过敏性体质患者外,并且首次服用后经过观察无变态反应者,耐酸、口服吸收好的青霉素V有较强的抗厌氧菌作用和良好的临床疗效。
From clinical isolates of oral anaerobic bacteria, except for Bacteroides fragilis 4, the other peptococcus and Streptococcus 14, Gram-positive Bacillus 4, and aerobic and facultative anaerobic alpha-hemolytic chain Four strains of cocci were sensitive to penicillin V, the clinical symptoms, the total number of white blood cells and the neutrophils in patients with acute periodontal and periapical infection were both MIC_ (50) ≤0.06 ~ 0.125mg / L and MIC_ (90) 0.125 ~ 0.25mg / Cell count was significantly improved and improved 3 days after taking penicillin V. Experimental results show that in addition to patients with allergic constitution, and after the first observation after no allergic reaction were observed, acid and oral absorption of good penicillin V has a strong anti-anaerobic effect and good clinical efficacy.